Nearly 600 ViaCord families have used their stored cord blood in a stem cell transplant or regenerative medicine clinical trial. Data on file ViaCord. October 2024. View ViaCord cord blood uses

Cord blood can be used in stem cell transplants for nearly 80 conditions to regenerate a healthy blood and immune system. Most of the conditions on the proven uses list are inherited genetic diseases. Typically, a child with a genetic disease who is in need of a transplant would require a cord blood unit from a sibling or an unrelated donor. However, there are some conditions on the list, like neuroblastoma cancer, where a child could use his or her own cord blood. Banking cord blood does not guarantee that treatment will work and only a doctor can determine when it can be used.  

1.) Hao QL, Shah AJ, Thiemann FT, Smogorzewska EM, Crooks GM. A functional comparison of CD34 + CD38- cells in cord blood and bone marrow. Blood. 1995 Nov 15;86(10):3745-53. PMID: 7579341. https://pubmed.ncbi.nlm.nih.gov/7579341/

2.) Parent's Guide to Cord Blood Foundation; Standard Diseases Treated by Cord Blood Transplant https://parentsguidecordblood.org/en/diseases

Some anemias, bone marrow failure disorders and cancers can be treated with a child's own cord blood stem cells. O’Brien TA, Tiedemann K, Vowels MR. No longer a biological waste product: umbilical cord blood. Med J Aust. 2006 184(8):407–410. Harris DT, Badowski M, Ahmad N, Gaballa MA. The potential of cord blood stem cells for use in regenerative medicine. Expert Opin Biol Ther. 2007;7(9):1311–1322. https://pubmed.ncbi.nlm.nih.gov/16618241/
 

Cord blood has been used for over 30 years in transplants (first cord blood transplant 1988) Broxmeyer, H. E., Cooper, S., Hangoc, G., Gluckman, E., Auerbach, A., Douglas, G. W., Friedman, H., Kurtzberg, J., Bard, J. and Boyse, E. A. (1990), Human umbilical cord blood: A clinically useful source of transplantable hematopoietic stem/progenitor cells. The International Journal of Cell Cloning, 8: 76–91. doi: 10.1002/stem.5530080708 https://pubmed.ncbi.nlm.nih.gov/1969886/
 

To date, there is no evidence that cord blood will ever expire. 
1) Hal Broxmeyer, Larry Luchsinger, Rona Weinberg, Alexandra Jimenez, Emeline Masson Frenet, Wouter van't Hof, Maegan Capitano, Christopher Hillyer, Mark Kaplan, Scott Cooper, James Ropa, Abstract 16 Insights into Highly Engraftable Hematopoietic Cells from 27-Year Cryopreserved Umbilical Cord Blood, Stem Cells Translational Medicine, Volume 12, Issue Supplement_1, September 2023, Page S18, https://doi.org/10.1093/stcltm/szad047.017

2) Liedtke S, Többen S, Gressmann H, Meyer A, Verde PE, Gluckman E, Kogler G. Long-Term Stability of Cord Blood Units After 29 Years of Cryopreservation: Follow-Up Data From the José Carreras Cord Blood Bank. Stem Cells Transl Med. 2024 Jan 12;13(1):30-42. doi: 10.1093/stcltm/szad071. PMID: 37936262; PMCID: PMC10785215. https://pubmed.ncbi.nlm.nih.gov/37936262/

Sibling up to 75% match, Full siblings have a 25% chance of being a perfect match and a 50% chance of being a partial match. Choo SY. The HLA system: genetics, immunology, clinical testing, and clinical implications. Yonsei Med J. 2007 Feb 28;48(1):11-23. doi: 10.3349/ymj.2007.48.1.11. PMID: 17326240; PMCID: PMC2628004. https://pmc.ncbi.nlm.nih.gov/articles/PMC2628004/

Mesenchymal Stem Cells are easily matched Klingemann H, Matzilevich D, Marchand J. Mesenchymal Stem Cells - Sources and Clinical Applications. Transfus Med Hemother. 2008;35(4):272-277. doi: 10.1159/000142333. Epub 2008 Jul 21. PMID: 21512642; PMCID: PMC3076359.

Cord blood use in clinical trials for Cerebral Palsy ClinicalTrials.gov, search term "Cerebral Palsy and Cord Bloodclincaltrials.gov  https://clinicaltrials.gov/search?cond=Cerebral%20Palsy&intr=cord%20blood%20 

Cord blood use in regenerative medicine clinical trials ClinicalTrials.gov http://www.clinicaltrials.gov  Search Other Terms “cord blood regenerative medicine”, “cord tissue regenerative medicine”
 

Cord blood stem cell therapy has great but unproven potential to significantly advance the treatment of patients with acquired and genetic brain diseases. Sun JM, Kurtzberg J. Cord blood for brain injury. Cytotherapy. 2015 Jun;17(6):775-785. doi: 10.1016/j.jcyt.2015.03.004. Epub 2015 Mar 19. PMID: 25800775.
https://pubmed.ncbi.nlm.nih.gov/25800775/
 

When optimally dosed, cord blood may improve motor function in young children with cerebral palsy. Jessica Sun, Mohamad Mikati, Jesse Troy, Kathryn Gustafson, Ryan Simmons, Ricki Goldstein, Jodi Petry, Colleen McLaughlin, Barbara Waters-Pick, Laura Case, Gordon Worley, Joanne Kurtzberg; Autologous Cord Blood Infusion for the Treatment of Brain Injury in Children with Cerebral Palsy. Blood 2015; 126 (23): 925. doi: https://doi.org/10.1182/blood.V126.23.925.925

Duke University: phase I study using sibling cord blood to treat children ages 1-6 years with cerebral palsy. National Institutes of Health, ClinicalTrials.gov. Assessment of the Safety of Allogeneic Umbilical Cord Blood Infusions in Children With Cerebral Palsy. https://clinicaltrials.gov/ct2/show/NCT02599207. Accessed January 18, 2016.
 

Storing cord blood in many compartments offers parents more options for participation in research studies. Driscoll, Kimberly A., Suzanne Bennett Johnson, Desmond A. Schatz, and Michael J. Haller. Use of a Precious Resource: Parental Decision Making about Using Autologous Umbilical Cord Blood in Studies Involving Young Children with Type 1 Diabetes. Contemporary Clinical Trials 32.4 (2011): 524-29.  Rosenau, Emma H., Michele W. Sugrue, Michael Haller, Diann Fisk, Susan S. Kelly, Myron Chang, Wei Hou, Lamis Eldjerou, William Slayton, Christopher R. Cogle, and John R. Wingard. " Characteristics of Thawed Autologous Umbilical Cord Blood.
 

ViaCord's method results in 8-times the number of cord tissue stem cells compared to other methods that extract cells from thawed frozen segments of cord tissue Briddell R, Litkenhaus F, Foertsch G, Fuhrmann A, Foster K, Falcon Girard K, Fiscus B, Boehm A, Brown M, Pettit M, Rigas Bridges A, Nichols K, Fodor W and Kraus M. Recovery of viable MSCs isolated from fresh umbilical cord tissue, measured after cryopreservation, is on average 8-fold higher when compared to recovery of viable MSCs isolated from previously cryopreserved umbilical cord tissue. Study sponsored by ViaCord. ASH Abstract submitted 2011 Aug. 11 https://www.sciencedirect.com/science/article/pii/S0006497119623219

If stem cell expansion technologies are perfected, having multiple compartments could be ideal. Rosenau, Emma H., Michele W. Sugrue, Michael Haller, Diann Fisk, Susan S. Kelly, Myron Chang, Wei Hou, Lamis Eldjerou, William Slayton, Christopher R. Cogle, and John R. Wingard. "Characteristics of Thawed Autologous Umbilical Cord Blood." Transfusion 52.10 (2012): 2234-242. Haller, M. J., C. H. Wasserfall, K. M. Mcgrail, M. Cintron, T. M. Brusko, J. R. Wingard, S. S. Kelly, J. J. Shuster, M. A. Atkinson, and D. A. Schatz. "Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes." Diabetes Care 32.11 (2009): 2041-046. https://pubmed.ncbi.nlm.nih.gov/22321210/
 
 

97% Celiac Disease Go Undiagnosed Although 97% of those with celiac disease go undiagnosed, earlier diagnosis lowers chance for developing other conditions. Source: Massachusetts General Hospital; Patient Education - Genetic Testing for Celiac Disease https://www.massgeneral.org/children/celiac-disease/genetic-testing-for-celiac-disease

Lactose Intolerance Lifestyle Alterations Lifestyle alterations can improve quality of life and overall digestive health. Source: Cleveland Clinic https://my.clevelandclinic.org/health/diseases/7317-lactose-intolerance

Genetic Testing For Celiac Disease The presence, absence, or a combination of these genes has been shown to be indicative of a predisposition for celiac disease. Source: Massachusetts General Hospital; Patient Education - Genetic Testing for Celiac Disease https://www.massgeneral.org/children/celiac-disease/genetic-testing-for-celiac-disease

Lactose Role of LCT Gene 
The LCT gene provides your body instructions for making an enzyme called lactase, which helps to digest lactose, a sugar found in milk and other dairy products. These variations have been shown to be indicative of a predisposition for lactose intolerance. Source: Mattar, R., de Campos Mazo, D. F., & Carrilho, F. J. (2012). Lactose intolerance: diagnosis, genetic, and clinical factors. Clinical and experimental gastroenterology, 5, 113–121. https://doi.org/10.2147/CEG.S32368 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401057/

Cord tissue stem cell properties Mesenchymal Stem Cell-Based Immunomodulation Wang M, Yuan Q, Xie L. Mesenchymal Stem Cell-Based Immunomodulation: Properties and Cliniccustomeral Application. Stem Cells Int. 2018 Jun 14;2018:3057624. doi: 10.1155/2018/3057624. PMID: 30013600; PMCID: PMC6022321. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022321/ 

HSCs are capable of generating the multitude of cell types found in the bloodstream, including red blood cells or erythrocytes; different types of white blood cells, such as lymphocytes and neutrophils; and megakaryocytes which ultimately form platelets. Metcalf D. Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions. Stem Cells. 2007 Oct;25(10):2390-5. doi: 10.1634/stemcells.2007-0544. Epub 2007 Aug 9. PMID: 17690176.
https://pubmed.ncbi.nlm.nih.gov/17690176/

Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into neuronal, pancreatic, hepatic, connective and structural tissues, giving them immense therapeutic potential. O’Brien TA, Tiedemann K, Vowels MR. No longer a biological waste product: umbilical cord blood. Med J Aust. 2006;184(8):407-410. Troyer DL, Weiss ML. Concise review: Wharton’s jelly-derived cells are a primitive stromal cell population. Stem Cells. 2008;26(3):591-599. https://pubmed.ncbi.nlm.nih.gov/16618241/

Cord Tissue stem cells are immunologically naive and more amenable to environmental change. Troyer DL, Weiss ML. Concise Review: Wharton’s jelly-derived cells are a primitive stromal cell population. Stem Cells. 2008;26:591-599. https://pubmed.ncbi.nlm.nih.gov/18065397/

 

MSCs can readily differentiate. Helmy KY, Patel SA, Silverio K, Pliner L, Rameshwar P. Stem cells and regenerative medicine: accomplishments to date and future promise. Ther Deliv. 2010 Nov;1(5):693-705. doi: 10.4155/tde.10.57. PMID: 21113422; PMCID: PMC2990533. https://pubmed.ncbi.nlm.nih.gov/21113422/

 

It's estimated that 1 in 3 people may benefit from regenerative medicine therapy.

1) Association for the Advancement of Biotherapies and Blood, Facts about Cellular Therapies - Regenerative Medicine
https://www.aabb.org/news-resources/resources/cellular-therapies/facts-about-cellular-therapies/regenerative-medicine#:~:text=Regenerative%20medicine%20may%20be%20defined,vessels%2C%20bladder%2C%20skin).

2) Harris DT. Stem Cell Banking for Regenerative and Personalized Medicine. Biomedicines. 2014 Feb 26;2(1):50-79. doi: 10.3390/biomedicines2010050. PMID: 28548060; PMCID: PMC5423479.https://pmc.ncbi.nlm.nih.gov/articles/PMC5423479/ 

3) Harris DT, Badowski M, Ahmad N, Gaballa MA. The potential of cord blood stem cells for use in regenerative medicine. Expert Opin Biol Ther. 2007 Sep;7(9):1311-22. doi: 10.1517/14712598.7.9.1311. PMID: 17727322. https://pubmed.ncbi.nlm.nih.gov/17727322/

4) 2008 Harris DT. Cord blood stem cells: a review of potential neurological applications. Stem Cell Rev. 2008 Dec;4(4):269-74. doi: 10.1007/s12015-008-9039-8. Epub 2008 Aug 5. PMID: 18679834.https://pubmed.ncbi.nlm.nih.gov/17727322/

More than 40,000 umbilical cord blood transplants have been performed worldwide. Ballen, K. (2017, August 24). Update on umbilical cord blood transplantation. Retrieved August 14, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580430/.

Properties of Stem Cells - Support Endogenous Repair
Kurtzberg J, Kosaras B, Stephens C, Snyder EY. Umbilical cord blood cells engraft and differentiate in neural tissues after human transplantation. Biol Blood Marrow Transplant 2003;9:128-9. Kyunghoon Min, MD, CP Epo Korean Study, Stem Cells, Translational and Clinical Research., 2012. Liu WS, Chen CT, Foo NH et al. Human umbilical cord blood cells protect against hypothalamic apoptosis and systemic inflammation response during heatstroke in rats. Pediatr Neonatol 2009;50:208-216. Dasari VR, Veeravalli KK, Saving KL et al.Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway. Neurobiol Dis 2008;32:486-498.

Duke University: Phase I clinical trial using autologous cord blood to treat children with cerebral palsy. Kurtzberg J. Status of a clinical trial of autologous cord blood stem cells for the treatment of cerebral palsy and other acquired brain injuries in young children. Poster presented at: 8th Annual International Umbilical Cord Blood Transplantation Symposium; June 3–5, 2010; San Francisco, CA.

Duke University: Phase II clinical trial using autologous cord blood to treat children with cerebral palsy. National Institutes of Health, ClinicalTrials.gov. A randomized study of autologous umbilical cord blood reinfusion in children with cerebral palsy. http://clinicaltrials.gov/ct2/show/NCT1147653. Identifier NCT01147653. Accessed November 21, 2011.

Cord blood studied to determine the effect on Autism.
Clinical Trials.gov. http://www.clinicaltrials.gov/ct2/show/NCT01638819. Accessed February 5, 2013.

Cord blood studied to determine the safety and efficacy with spinal cord injuries. Clinical Trials.gov. http://www.clinicaltrials.gov/ct2/show/NCT01046786. Accessed February 5, 2013.

Clinical trials conducted to test the utility of autologous umbilical cord blood infusions to treat autism, cerebral palsy, and type 1 diabetes. National Institutes of Health, ClinicalTrials.gov. Autologous Cord Blood Stem Cells for Autism. http://clinicaltrials.gov/show/NCT01638819. Identifier NCT01638819. Accessed March 9, 2015. National Institutes of Health, ClinicalTrials.gov. Umbilical Cord Blood Infusion to Treat Type 1 Diabetes. http://clinicaltrials.gov/ct2/show/NCT00305344. Identifier NCT00305344. Accessed September 11, 2012. National Institutes of Health, ClinicalTrials.gov. A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children with Cerebral Palsy. http://clinicaltrials.gov/ct2/show/NCT1147653. Identifier NCT01147653. Accessed September 11, 2012.

Clinical trials using cord blood stem cells in the treatment of heart disease. Sodian R, Lueders C, Kraemer L, Kuebler W, Shakibaei M, Reichart B, Daebritz S, Hetzer R. Tissue engineering of autologous human heart valves using cryopreserved vascular umbilical cord cells. Ann Thorac Surg. 2006 Jun;81(6):2207-16. doi:10.1016/j.athoracsur.2005.12.073. PMID: 16731156 https://pubmed.ncbi.nlm.nih.gov/16731156/

Clinical trial using cord blood stem cells in the treatment of Alzheimer’s disease.
1) Lee HJ, Lee JK, Lee H, Carter JE, Chang JW, Oh W, Yang YS, Suh JG, Lee BH, Jin HK, Bae JS. Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation. Neurobiol Aging. 2012 Mar;33(3):588-602. doi: 10.1016/j.neurobiolaging.2010.03.024. Epub 2010 May 14. PMID: 20471717. https://pubmed.ncbi.nlm.nih.gov/20471717/

2)  Ende N, Chen R, Ende-Harris D. Human umbilical cord blood cells ameliorate Alzheimer's disease in transgenic mice. Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School. J Med. 2001;32(3-4):241-7. https://pubmed.ncbi.nlm.nih.gov/11563821/

Clinical trials using cord tissue stem cells in the treatment of Multiple Sclerosis. Nanjing University Medical College Affiliated Drum Tower Hospital. Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica. http://clinicaltrials.gov/ct2/show/NCT01364246. Identifier NCT01364246. Accessed May 2, 2014. Translational Biosciences. Feasibility Study of Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells in Patients With Multiple Sclerosis. http://clinicaltrials.gov/ct2/show/NCT02034188. Identifier NCT02034188. Accessed May 2, 2014. Freedman, M. S., A. Bar-Or, H. L. Atkins, D. Karussis, F. Frassoni, H. Lazarus, N. Scolding, S. Slavin, K. Le Blanc, and A. Uccelli. "The Therapeutic Potential of Mesenchymal Stem Cell Transplantation as a Treatment for Multiple Sclerosis: Consensus Report of the International MSCT Study Group." Multiple Sclerosis 16.4 (2010): 503-10.

Duke University: Autologous Umbilical Cord Blood Infusion for Children With Autism Spectrum Disorder (ASD) National Institutes of Health, ClinicalTrials.gov. Autologous Umbilical Cord Blood Infusion for Children With Autism Spectrum Disorder (ASD). https://clinicaltrials.gov/ct2/show/NCT02176317. Accessed July 7, 2014.

Characteristics of cord blood stem cells that could potentially provide benefit to children with Autism Spectrum Disorder.
Kurtzberg J, Kosaras B, Stephens C, Snyder EY. Umbilical cord blood cells engraft and differentiate in neural tissues after human transplantation. Biol Blood Marrow Transplant 2003;9:128-9. Haller, Exp Hematol. 2008 June;36(6); 710-715. Kurtzberg, et.al. 2014. J. of Peds. Feasibility of Autologous Cord Blood Cells for Infants with Hypoxic-Ischemic Encephalopathy. Translational Med, 11; 195, 2013. Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism. Stroke. 2001. Chopp. IV Adm of UCB in Stroke. Kyunghoon Min, MD, CP Epo Korean Study, Stem Cells, Translational and Clinical Research., 2012. Translational Med. Stem Cell Therapy for Autism: Review. Park DH, Borlongan CV, Willing AE, Eve DJ, Cruz LE, Sanberg CD, Chung YG, Sanberg PR: Human umbilical cord blood cell grafts for brain ischemia. Cell Transplant 2009, 18(9):985-998. Liu WS, Chen CT, Foo NH et al. Human umbilical cord blood cells protect against hypothalamic apoptosis and systematic inflammation response during heatstroke in rats. Pediatr Neonatol 2009;50:208-216. Dasari VR, Veeravalli KK, Saving KL et al. Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway. Neurobiol Dis 2008;32:486-498.

Family (Private) cord blood banking may serve a purpose as ‘medical insurance’ if regenerative techniques prove fruitful. KK Ballen, F Verter and J Kurtzberg. “Umbilical cord blood donation: public or private?” Bone Marrow Transplantation (2015), 1–8, advance online publication, 1 June 2015; doi:10.1038/bmt.2015.124
https://pubmed.ncbi.nlm.nih.gov/26030051/

Storing cord blood in many compartments offers parents more options for participation in research studies.

1.) Driscoll KA, Johnson SB, Schatz DA, Haller MJ. Use of a precious resource: parental decision making about using autologous umbilical cord blood in studies involving young children with type 1 diabetes. Contemp Clin Trials. 2011 Jul;32(4):524-9. doi: 10.1016/j.cct.2011.04.004. Epub 2011 Apr 17. PMID: 21530680; PMCID: PMC3129744. https://pmc.ncbi.nlm.nih.gov/articles/PMC3129744/

2.) Rosenau, Emma H., Michele W. Sugrue, Michael Haller, Diann Fisk, Susan S. Kelly, Myron Chang, Wei Hou, Lamis Eldjerou, William Slayton, Christopher R. Cogle, and John R. Wingard. "Characteristics of Thawed Autologous Umbilical Cord Blood." Transfusion 52.10 (2012): 2234-242. https://pubmed.ncbi.nlm.nih.gov/22321210/

If regenerative medicine research using cord blood shows beneficial effect, multiple dosing could be more advantageous than a single dose.
Sun JM, Grant GA, McLaughlin C, Allison J, Fitzgerald A, Waters-Pick B, Kurtzberg J. Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus. Pediatr Res. 2015 Dec;78(6):712-6. doi: 10.1038/pr.2015.161. Epub 2015 Sep 2. PMID: 26331765. https://pubmed.ncbi.nlm.nih.gov/26331765/

Hu H, Zhao Q, Liu X, Yan T. Human umbilical cord blood cells rescued traumatic brain injury-induced cardiac and neurological deficits. Ann Transl Med. 2020 Mar;8(6):278. doi: 10.21037/atm.2020.03.52. PMID: 32355722; PMCID: PMC7186665. https://pmc.ncbi.nlm.nih.gov/articles/PMC7186665/

 
Nguyen T, Purcell E, Smith MJ, Penny TR, Paton MCB, Zhou L, Jenkin G, Miller SL, McDonald CA, Malhotra A. Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury: A Systematic Review & Meta-Analysis of Preclinical Studies. Int J Mol Sci. 2023 Feb 22;24(5):4351. doi: 10.3390/ijms24054351. PMID: 36901781; PMCID: PMC10001969.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10001969

 
Results of the Type 1 Diabetes study showed the treatment to be feasible and safe. Efficacy could not be demonstrated due to the follow-up study's small sample size. Michael J. Haller, Clive H. Wasserfall, Kieran M. Mcgrail, et al. "Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes" Diabetes Care. 2009 Nov; 32(11): 2041–2046. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768209/ doi: 10.2337/dc09-096Michael J. Haller, Clive H. Wasserfall, et al. "Autologous Umbilical Cord Blood Infusion followed by Oral Docosahexaenoic Acid and Vitamin D Supplementation for C-Peptide Preservation in Children with Type 1 Diabetes". 2013 Apr 20. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852705/ doi: 10.1016/j.bbmt.2013.04.011

Cord blood studied for Acquired Hearing Loss Florida Hospital; Safety of Autologous Stem Cell Infusion for Children with Acquired Hearing Loss. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2015- [cited 2015 Feb 10]. Available from: https://clinicaltrials.gov/ct2/show/NCT02038972 NLM Identifier: NCT02038972

 
Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome This is a Phase I study to determine the safety and feasibility of injections of autologous umbilical cord blood (UCB) cells into the right ventricle of Hypoplastic Left Heart Syndrome (HLHS) children undergoing a scheduled Glenn surgical procedure. The investigators are doing this research study to find out if autologous stem cells from the individual's own umbilical cord blood can be used to strengthen the muscle of the right side of their heart. This will help determine the safety and feasibility of using cell-based regenerative therapy as an additional treatment for the management of HLHS. https://www.clinicaltrials.gov/ct2/show/NCT01883076?term=hlhs+cord+blood&rank=3

Properties of Stem Cells - Neural pathway remodeling, neuroprotective.

1)  Lv YT, Zhang Y, Liu M, Qiuwaxi JN, Ashwood P, Cho SC, Huan Y, Ge RC, Chen XW, Wang ZJ, Kim BJ, Hu X. Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism. J Transl Med. 2013 Aug 27;11:196. doi: 10.1186/1479-5876-11-196. PMID: 23978163; PMCID: PMC3765833. https://pubmed.ncbi.nlm.nih.gov/23978163/

2) Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, Sanchez-Ramos J, Chopp M. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001 Nov;32(11):2682-8. doi: 10.1161/hs1101.098367. PMID: 11692034.
https://pubmed.ncbi.nlm.nih.gov/11692034/#:~:text=Intravenous%20administration%20of%20human%20umbilical,098367.
 

Properties of Stem Cells - Immune modulation, anti-inflammatory

Kurtzberg, et.al. 2014. J. of Peds. Feasibility of Autologous Cord Blood Cells for Infants with Hypoxic-Ischemic Encephalopathy.

 
ViaCord's Whole Genome Sequencing 1 in 12 apparently healthy newborns carried genetic findings that could impact their health from an early age. Balciuniene J, Liu R, Bean L, et al. At-Risk Genomic Findings for Pediatric-Onset Disorders From Genome Sequencing vs Medically Actionable Gene Panel in Proactive Screening of Newborns and Children. JAMA Netw Open. 2023;6(7):e2326445. doi:10.1001/jamanetworkopen.2023.26445 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807782

Whole Genome Sequencing Adults 1 in 5 had a previously unrecognized variant with potential risk for a rare inherited disease.  Jason L. Vassy, Kurt D. Christensen, Erica F. Schonman, et al; for the MedSeq Project . The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial. Ann Intern Med.2017;167:159-169. [Epub 27 June 2017]. doi:10.7326/M17-0188 https://www.acpjournals.org/doi/10.7326/M17-0188

ViaCord's Processing & Storage Laboratory Accreditations

• View ViaCord's FDA Registration
• View ViaCord's AABB Accreditation
• View ViaCord's; CLIA Certificate
   

ViaCord's Processing & Storage Laboratory has a class 100,000 clean room and FEMA grade storage vault. Data on file. ViaCord.