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Treatable Diseases and Future Uses of Umbilical Cord Blood Stem Cells

Today, cord blood stems cells are used in the treatment of over 40 life-threatening diseases, including a wide range of cancers, genetic diseases, immune system deficiencies, and blood disorders (see list below).

To learn more about potential future uses for cord blood stem cells click here.

Cancers
 

  • Acute lymphoblastic leukemia (ALL)
  • Acute myelogenous leukemia (AML)
  • Burkitt's lymphoma
  • Chronic myelogenous leukemia (CML)
  • Juvenile chronic myelogenous leukemia (JCML)
  • Juvenile myelomonocytic leukemia (JMML)
  • Liposarcoma
  • Myelodysplastic syndrome (MDS)
  • Chronic myelomonocytic leukemia (CMML)
  • Neuroblastoma
  • Non-Hodgkin's lymphoma
  • Hodgkin's lymphoma

Bone Marrow Failure Systems
 

  • Severe aplastic anemia
  • Diamond-Blackfan anemia
  • Dyskeratosis congenita
  • Fanconi anemia
  • Amegakaryocytic thrombocytopenia
  • Kostmann's syndrome

Hemoglobinpathies/Blood Disorders
 

  • Sickle-cell anemia
  • ß-Thalassemia (Cooley's anemia)

Inborn Errors of Metabolism
 

  • Adrenoleukodystrophy
  • Batten disease (inherited neuronal ceroid lipofuscinosis)
  • Gunther disease
  • Hunter syndrome
  • Hurler syndrome
  • Krabbe disease (globoid cell leukodystrophy)
  • Lesch-Nyhan disease
  • Maroteaux-Lamy syndrome

Immunodeficiencies
 

  • Omenn's syndrome
  • Severe combined immune deficiency (SCID and SCID-ADA)
  • Reticular dysplasia
  • Thymic dysplasia
  • Wiskott-Aldrich syndrome
  • X-linked lymphoproliferative disease
  • Leukocyte adhesion deficiency

Other Diseases
 

  • Langerhan's cell histiocytosis
  • Evans syndrome
  • Familial hemaphagocytic lymphohistiocytosis
  • EBV-assoc. hemophagocytic lymphohistiocytosis
  • Osteopetrosis

Although the potential use of umbilical cord blood is expanding rapidly, the odds that family member without a defined risk will need to use their child's umbilical cord blood are low. There is no guarantee that the umbilical cord blood will be a match for a family member or will provide a cure. Autologous cord blood stem cells will not guarantee suitable treatment for all inherited genetic diseases. As with any transplant therapy, therapeutic success depends upon many factors beyond the stem cells themselves including patient condition, type of disease, recipient-donor relationship and matching, and other factors.

 

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